Molecular Metabolism: Cov nyhuv kho ntawm NMN supplementation ntawm polycystic zes qe menyuam syndrome

Nyob rau hauv xyoo tas los no, nrog kev nce ntawm kev ua neej tsis zoo thiab kev sib raug zoo ntawm cov poj niam, qhov tshwm sim ntawm polycystic zes qe menyuam syndrome (PCOS) tau dhau los ua qhov pom tseeb.Cov kev tshawb fawb txawv teb chaws tau pom tias qhov tshwm sim ntawm polycystic zes qe menyuam syndrome (PCOS) nyob rau hauv cov poj niam ntawm cov me nyuam muaj hnub nyoog yog siab li 6% -15%, thaum nyob rau hauv Tuam Tshoj, qhov feem ntau yog siab li 6% -10%.

Polycystic zes qe menyuam syndrome yog ib tug kab mob uas feem ntau tshwm sim nyob rau hauv cov poj niam ntawm cov me nyuam muaj hnub nyoog vim yog endocrine ntshawv siab.Nws yog feem ntau tshwm sim nyob rau hauv cov piam thaj thiab lipid metabolism tsis zoo thiab kev ua me nyuam tsis ua haujlwm.Cov kev kuaj mob hauv tsev kho mob yog cov tshuaj hormones tsis meej (siab androgen), dilute Ovulation disorders thiab zes qe menyuam polycystic hloov, thiab feem ntau cov poj niam nrog PC COS muaj cov yam ntxwv tsis zoo, xws li insulin tsis kam, rog, thiab hepatic steatosis.

Tam sim no, muaj ob peb yam tshuaj rau kev kho mob ntawm PCOS.Txoj hauv kev zoo tshaj plaws yog los txhim kho PCOS los ntawm kev tsom thiab inhibiting androgen tshaj nrog cov tshuaj tiv thaiv androgen .Txawm li cas los xij, tseem muaj pov thawj tias cov tshuaj tiv thaiv androgen muaj lub siab toxicity, yog li lawv siv tsawg.Yog li ntawd, nws yog ib qho tseem ceeb heev kom nrhiav tau ib yam khoom ntuj uas tsis muaj kev phiv los hloov cov tshuaj tam sim no.

Kev tshawb fawb tsis ntev los no los ntawm University of New South Wales hauv Australia tau pom tias polycystic zes qe menyuam syndrome muaj feem xyuam nrog NAD + deficiency, thiab cov txiaj ntsig kev tshawb fawb tau luam tawm hauv phau ntawv xov xwm tshawb fawb "Molecular Metabolism".

Pab pawg tshawb fawb thawj zaug cog dihydrotestosterone (DHT) subcutaneously hauv cov poj niam nas ua ntej thiab tom qab kev laus los tsim ib tus qauv PC COS nas, thiab tom qab ntawd tom qab 8 lub lis piam ntawm NMN kev kho mob, yoo mov insulin thiab HOMA insulin tsis kam, kuaj ntshav qabzib, rog tom qab kuaj xws li Raws li histomorphometry, cov txiaj ntsig txheeb cais qhia:

1. N MN restores N AD + qib hauv cov leeg ntawm P COS nas
pom tias NAD + qib hauv cov leeg ntawm PCOS nas tau txo qis, thiab qib NAD hauv cov leeg ntawm PCOS nas tau rov qab los ntawm NMN noj.

2. NMN txhim kho insulin tsis kam thiab rog rog hauv PCOS nas
DHT-induced insulin ntau dua ob npaug ntawm cov nas PCOS yoo mov, tejzaum nws cuam tshuam txog cov tshuaj insulin.Los ntawm kev noj NMN, nws tau pom tias cov qib insulin yoo mov tau rov qab mus rau qib ze rau cov nas ib txwm muaj.Tsis tas li ntawd, lub cev hnyav ntawm PCOS nas tau nce 20%, thiab cov rog rog tau nce ntau.

3. NMN rov kho cov kab mob siab lipid tso rau hauv PCOS nas
Ib qho ntawm cov yam ntxwv ntawm polycystic zes qe menyuam syndrome yog lipid deposition nyob rau hauv daim siab thiab induction ntawm fatty daim siab.Tom qab noj NMN, qhov txawv txav ntawm daim siab lipid deposition hauv PCOS nas yuav luag raug tshem tawm, thiab cov triglycerides hauv daim siab rov qab mus rau qib ntawm cov nas qub.

xaus, theem ntawm NAD + hauv cov leeg ntawm PCOS tau txo qis, thiab cov xwm txheej ntawm PCOS tau txo qis los ntawm kev ntxiv NMN, tus thawj coj ntawm NAD +, uas tej zaum yuav yog lub peev xwm kho mob rau kev kho mob ntawm PCOS.

cov ntaub ntawv:
[1].Aflatounian A, Paris VR, Richani D, Edwards MC, Cochran BJ, Ledger WL, Gilchrist RB, Bertoldo MJ, Wu LE, Walters KA.Txo cov leeg nqaij NAD + hauv hyperandrogenism PCOS nas qauv: Ua tau lub luag haujlwm hauv metabolic dysregulation.Mol Metab.2022 Peb 9:101583.doi: 10.1016/j.molmet.2022.101583.Epub ua ntej luam tawm.PIB: 36096453.