Radiation-induced plab hnyuv fibrosis yog ib qho teeb meem ntawm cov neeg muaj sia nyob mus ntev tom qab kev kho mob plab thiab plab hnyuv.Tam sim no, tsis muaj txoj hauv kev kho mob los kho cov kab mob qog nqaij hlav hauv plab hnyuv.Cov kev tshawb fawb tau pom tias nicotinamide mononucleotide (NMN) muaj peev xwm tswj tau cov hnyuv.Cov kab mob hauv plab yog ib txwm muaj kab mob hauv tib neeg cov hnyuv, uas tuaj yeem ua ke ntau yam khoom noj uas tsim nyog rau tib neeg kev loj hlob thiab kev loj hlob.Thaum lub plab hnyuv tawm ntawm qhov sib npaug, nws yuav ua rau ntau yam kab mob.
Tsis ntev los no, Tuam Tshoj Academy ntawm Kev Kho Mob Sciences thiab Peking Union Medical College tau luam tawm cov kev tshawb fawb hauv phau ntawv Journal International Journal of Radiation Biology, uas qhia tias NMN tuaj yeem txo cov plab hnyuv fibrosis los ntawm hluav taws xob los ntawm kev tswj cov hnyuv.
Thaum xub thawj, pab pawg tshawb fawb tau faib cov nas rau hauv pawg tswj hwm, NMN pawg, IR pawg thiab NMNIR pawg, thiab muab 15 Gy plab irradiation rau IR pawg thiab NMNIR pawg.Lub caij no, NMN ntxiv tau muab rau NMN pawg thiab NMNIR pawg ntawm ib hnub koob tshuaj 300mg / kg.Tom qab noj nws rau qee lub sijhawm, los ntawm kev kuaj nas cov quav, plab hnyuv microflora thiab cov kab mob plab hnyuv, cov txiaj ntsig sib piv tau pom tias:
1. NMN tuaj yeem kho qhov muaj pes tsawg leeg thiab kev ua haujlwm ntawm cov hnyuv uas cuam tshuam los ntawm hluav taws xob.
Los ntawm kev sib piv cov kev tshawb pom ntawm cov hnyuv ntawm IR pawg thiab NMNIR pab pawg, nws tau pom tias IR pab pawg nas tau nce ntau ntawm cov kab mob plab hnyuv, xws li Lactobacillus du, Bacillus faecalis, thiab lwm yam. Kuj ceeb tias, NMNIR pab pawg nas tau hloov ntau yam ntawm cov hnyuv. thiab nce kev nplua nuj ntawm cov hnyuv muaj txiaj ntsig, xws li cov kab mob AKK, los ntawm kev ntxiv NMN.Cov kev sim qhia tau hais tias NMN tuaj yeem kho qhov muaj pes tsawg leeg thiab kev ua haujlwm ntawm cov hnyuv uas tawm ntawm qhov sib npaug vim hluav taws xob.
2. NMN alleviates plab hnyuv fibrosis tshwm sim los ntawm hluav taws xob
Qib ntawm aSMA (Fibrosis Marker) hauv cov nas uas raug hluav taws xob tau nce ntxiv.Tom qab NMN supplementation, tsis tsuas yog qib ntawm aSMA marker txo qis, tab sis kuj muaj qhov ua rau TGF-b uas txhawb cov hnyuv fibrosis txo qis, qhia tias NMN supplementation tuaj yeem txo cov plab hnyuv fibrosis los ntawm hluav taws xob.
(Daim duab 1. NMN kev kho mob txo cov plab hnyuv fibrosis los ntawm hluav taws xob)
Raws li keeb kwm yav dhau los ntawm kev nthuav dav ntawm cov khoom siv hluav taws xob, hluav taws xob muaj kev cuam tshuam ntau ntxiv rau tib neeg txoj haujlwm thiab lub neej, tshwj xeeb tshaj yog nyob rau hauv cov hnyuv rau lub sijhawm ntev.NMN muaj kev tiv thaiv zoo rau txoj hnyuv.Cov nyhuv no tsis yog tsuas yog pom tau los ntawm ib qho tshuaj lossis ib txoj hauv kev, tab sis kuj los ntawm kev tswj cov qauv kev faib tawm ntawm cov nroj tsuag los txhawb kev ruaj ntseg ntawm txoj hnyuv ua haujlwm los ntawm ntau lub kaum ntse ntse thiab cov lus qhia, uas tseem muab cov ntaub ntawv tseem ceeb rau ntau yam txiaj ntsig ntawm NMN.
Cov ntaub ntawv:
Xiaotong Zhao, Kaihua Ji, Manman Zhang, Hao Huang, Feng Wang, Yang Liu & Qiang Liu (2022): NMN alleviates radiation-induced plab hnyuv fibrosis los ntawm modulating plab microbiota, International Journal of Radiation Biology, DOI: 10.1080/092215030
Post lub sij hawm: Dec-08-2022