Clenbuterol, yog ib qho β2-adrenergic agonist (β2-adrenergic agonist), zoo ib yam li ephedrine (Ephedrine), feem ntau siv rau hauv kev kho mob los kho tus kab mob ntsws ntev (COPD), Nws kuj tseem siv ua lub bronchodilator los txo qhov mob hnyav ntawm hawb pob. Thaum ntxov xyoo 1980, lub tuam txhab Asmeskas Cyanamid tau pom tias nws muaj cov txiaj ntsig pom tseeb ntawm kev txhawb nqa kev loj hlob, txhim kho cov nqaij ntshiv thiab txo cov rog, yog li nws tau siv ua clenbuterol hauv kev yug tsiaj. Txawm li cas los xij, vim nws cov kev mob tshwm sim, Lub Zej Zog European tau txwv tsis pub siv clenbuterol ua cov khoom noj ntxiv txij li Lub Ib Hlis 1, 1988. Nws tau raug txwv los ntawm FDA hauv xyoo 1991. Xyoo 1997, Ministry of Agriculture ntawm People's Republic of China tau txwv tsis pub siv cov tshuaj hormones beta-adrenergic hauv kev yug tsiaj thiab kev yug tsiaj, thiab Clenbuterol hydrochloride tau qeb duas thawj zaug.
Txawm li cas los xij, Clenbuterol uas muaj racemic tsis ntev los no tau pom tias txo qhov kev pheej hmoo ntawm tus kab mob Parkinson. Txhawm rau kom paub meej tias cov isomers twg (lossis ob qho tib si) tsim cov teebmeem no, Clenbuterol enantiomer ntshiab yuav tsum tau kawm cais.
Hauv tsab xov xwm tsis ntev los no, pawg neeg tshawb fawb ntawm Elisabeth Egholm Jacobsen ntawm Lub Tsev Haujlwm Saib Xyuas Chemistry, Norwegian University of Science thiab Technology, koom tes nrog Dr. Zhu Wei ntawm Shangke Bio, tau ua rau muaj kev sib xyaw ua ke ntawm ketoreductase KRED thiab cofactor nicotinamide adenine dinucleoside phosphate (NADPH). (R)-1-(4-Amino-3,5-dichlorophenyl)-2-bromoethan-1-ol, ee > 93%; thiab (S)-N-(2 tau tsim los ntawm tib lub kaw lus, 6-Dichloro-4-(1-hydroxyethyl)phenyl)acetamide, ee > 98%. Ob qho tib si ntawm cov intermediates saum toj no yog cov peev xwm ua ntej ntawm clenbuterol isomers. Tus ketoreductase ES-KRED-228 siv rau hauv txoj kev tshawb no yog los ntawm Shangke Biopharmaceutical (Shanghai) Co., Ltd. Cov txiaj ntsig tshawb fawb "Chemoenzymatic Synthesis of Synthons as Precursors for Enantiopure Clenbuterol and Other -2-Agonists" tau luam tawm hauv "Catalysts" rau lub Kaum Ib Hlis 4, 2018.
Lub sijhawm tshaj tawm: Lub Yim Hli-26-2022