Clenbuterol, yog ib tug β2-adrenergic agonist (β2-adrenergic agonist), zoo ib yam li ephedrine (Ephedrine), feem ntau yog siv nyob rau hauv kev kho mob los kho cov mob ntsws obstructive pulmonary disease (COPD), Nws kuj yog siv raws li ib tug bronchodilator los txo tus mob exacerbations ntawm hawb pob.Thaum xyoo 1980s, lub tuam txhab Asmeskas Cyanamid yuam kev pom tias nws muaj cov txiaj ntsig zoo ntawm kev txhawb nqa kev loj hlob, txhim kho cov nqaij ntshiv thiab txo cov rog, yog li nws tau siv los ua clenbuterol hauv kev ua tsiaj txhu.Txawm li cas los xij, vim nws cov kev mob tshwm sim, Cov Neeg European tau txwv tsis pub siv clenbuterol ua cov khoom noj ntxiv txij thaum Lub Ib Hlis 1, 1988. Nws tau txwv los ntawm FDA hauv xyoo 1991. Xyoo 1997, Ministry of Agriculture ntawm Cov Neeg Sawv Cev ntawm Tuam Tshoj txwv nruj heev. Kev siv cov tshuaj hormones beta-adrenergic hauv kev noj zaub mov thiab tsiaj yug tsiaj, thiab Clenbuterol hydrochloride yog thawj.
Txawm li cas los xij, racemic Clenbuterol tsis ntev los no tau pom tias txo qis kev pheej hmoo ntawm Parkinson tus kab mob.Yuav kom paub meej tias leej twg (los yog ob qho tib si) isomers tsim cov nyhuv no, cov ntshiab Clenbuterol enantiomer yuav tsum tau kawm cais.
Nyob rau hauv ib tsab xov xwm tsis ntev los no, pawg tshawb fawb ntawm Elisabeth Egholm Jacobsen ntawm Department of Chemistry, Norwegian University of Science thiab Technology, koom tes nrog Dr. Zhu Wei ntawm Shangke Bio, catalyzed lub synthesis ntawm ketoreductase KRED thiab cofactor nicotinamide adenine dinucleoside PHNAD phosphate ( ).(R)-1-(4-Amino-3,5-dichlorophenyl)-2-bromoethan-1-ol, ee > 93%;thiab (S)-N-(2 yog synthesized los ntawm tib lub cev, 6-Dichloro-4-(1-hydroxyethyl)phenyl)acetamide, ee> 98%.Ob leeg ntawm cov neeg nruab nrab saum toj no yog cov muaj peev xwm ua ntej ntawm clenbuterol isomers.Lub ketoreductase ES-KRED-228 siv nyob rau hauv txoj kev tshawb no yog los ntawm Shangke Biopharmaceutical (Shanghai) Co., Ltd. Qhov kev tshawb fawb tau "Chemoenzymatic Synthesis ntawm Synthons li Precursors rau Enantiopure Clenbuterol thiab Lwm yam -2-Agonists" tau luam tawm nyob rau hauv "Catalysts" nyob rau Kaum Ib Hlis 4, 2018.
Post lub sij hawm: Aug-26-2022