Hypopigmentation yog kab mob ntawm daim tawv nqaij, feem ntau tshwm sim los ntawm kev txo melanin.Cov tsos mob tshwm sim muaj xws li vitiligo, albinism thiab hypopigmentation tom qab daim tawv nqaij o.Tam sim no, kev kho mob tseem ceeb rau hypopigmentation yog cov tshuaj hauv qhov ncauj, tab sis cov tshuaj hauv qhov ncauj yuav ua rau daim tawv nqaij atrophy, plab hnyuv tsis xis nyob thiab lwm yam kev mob tshwm sim.Yog li ntawd, nws yog ib qho tsim nyog los tsim cov khoom ntuj uas tsis muaj kev phiv los kho hypopigmentation.
Tsis ntev los no, Kev Tshaj Tawm Txog Kev Tshawb Fawb tau luam tawm ib tsab xov xwm hu ua "Kev tshawb nrhiav kev tshawb fawb qhia txog lub peev xwm ntawm spermidine rau kev kho mob hypopigmentation | los ntawm kev ruaj khov ntawm melanogenesis-txuas nrog cov proteins".Cov txiaj ntsig tau pom tias spermidine tuaj yeem kho tau los ntawm stabilizing melanogenesis-txuas nrog cov proteins.hypopigmentation.
Ib, Spermidine kev kho mob nce melanin ntau lawm
Txhawm rau kawm txog cov txiaj ntsig ntawm spermidine ntawm melanin ntau lawm, pab pawg tshawb fawb tau kho cov melanin hauv MNT-1 hlwb nrog ntau qhov sib txawv ntawm cov spermidine.Los ntawm kev soj ntsuam ntau, nws tau pom tias kev kho spermidine nce melanin ntau lawm.
二 、 Spermidine tuaj yeem tswj cov protein degradation system ntsig txog melanogenesis
Txhawm rau ua pov thawj tias spermidine tuaj yeem tswj hwm cov noob muaj feem cuam tshuam nrog cov protein degradation, pab pawg tshawb fawb pom 181 genes down regulated thiab 82 genes up controled by systematically detects spermidine treatment cells, excluding genes related to melanogenesis.Txhawm rau ua pov thawj ntxiv, pab pawg tshawb fawb tau tshuaj xyuas cov txiaj ntsig ntawm spermidine ntawm kev qhia theem ntawm tyrosinase gene tsev neeg TYR, TRP-1 thiab TRP-2, uas yog cov noob tswj xyuas melanin ntau lawm.mRNA qhia theem tau lees paub tias spermidine tsis hloov qhov kev qhia ntawm melanogenesis ntsig txog cov noob.Txawm li cas los xij, kev ua haujlwm ntawm ntau cov noob tau hloov pauv los ntawm spermidine thiab cuam tshuam rau cov protein degradation.Ntau cov noob hloov pauv muaj feem cuam tshuam rau qhov chaw nyob, uas yog cov txheej txheem degradation protein cuam tshuam rau melanogenesis.
Spermidine tswj kev ruaj ntseg ntawm cov proteins thiab txhawb kev tsim melanin.
Kev tsim cov melanin yog tswj hwm los ntawm kev sib npaug ntawm kev sib txuas thiab degradation ntawm melanin ntsig txog cov proteins.Spermidine kho TYR, TRP-1 thiab TRP-2 noob.Los ntawm qhov kev txiav txim ntawm cov noob caj noob ces SLC3A2, SLC7A1, SLC18B1 thiab SLC22A18, nws tuaj yeem nce qib ntawm polyamines hauv cov hlwb, yog li ua kom muaj kev ruaj ntseg ntawm cov protein uas cuam tshuam nrog melanin ntau lawm los txhawb melanin ntau lawm hauv vivo.
Nyob rau hauv xaus, txoj kev tshawb no qhia tau hais tias lub ntuj compound spermidine muaj peev xwm ua lub luag hauj lwm nyob rau hauv kev kho mob ntawm hypopigmentation, thiab muaj tej yam nqi ntawm daim ntawv thov nyob rau hauv lub teb ntawm tshuaj pleev ib ce thiab cov khoom noj qab haus huv yav tom ntej.
Siv:
[1]. Brito, S., Heo, H., Cha, B. et al.Kev tshawb nrhiav kev tshawb fawb qhia txog lub peev xwm ntawm spermidine rau kev kho hypopigmentation los ntawm kev ruaj khov ntawm melanogenesis-uas cuam tshuam cov proteins.Sci Rep 12, 14478 (2022).https://doi.org/10.1038/s41598-022-18629-3.
Post lub sij hawm: Sep-28-2022