Hypopigmentation yog ib yam kab mob ntawm daim tawv nqaij, feem ntau yog tshwm sim los ntawm kev txo qis melanin. Cov tsos mob feem ntau suav nrog vitiligo, albinism thiab hypopigmentation tom qab o ntawm daim tawv nqaij. Tam sim no, kev kho mob tseem ceeb rau hypopigmentation yog tshuaj noj, tab sis tshuaj noj yuav ua rau daim tawv nqaij atrophy, mob plab hnyuv thiab lwm yam kev phiv tsis zoo. Yog li ntawd, nws yog qhov tsim nyog los tsim cov tshuaj ntuj tsis muaj kev phiv los kho hypopigmentation.
Tsis ntev los no, Scientific Reports tau tshaj tawm ib tsab xov xwm hu ua "Kev tshawb nrhiav tsis tu ncua qhia txog lub peev xwm ntawm spermidine rau kev kho mob hypopigmentation | los ntawm kev ruaj khov ntawm cov proteins uas cuam tshuam nrog melanogenesis". Cov txiaj ntsig qhia tau tias spermidine tuaj yeem kho tau los ntawm kev ruaj khov cov proteins uas cuam tshuam nrog melanogenesis. hypopigmentation.
Ib qho, kev kho mob Spermidine ua rau melanin ntau ntxiv
Yuav kom kawm txog cov nyhuv ntawm spermidine rau kev tsim melanin, pab pawg tshawb fawb tau kho cov melanin hauv MNT-1 hlwb nrog cov tshuaj spermidine sib txawv. Los ntawm kev tshuaj xyuas ntau yam, pom tias kev kho spermidine ua rau muaj melanin ntau ntxiv.
2. Spermidine tuaj yeem tswj cov protein degradation system ntsig txog melanogenesis
Yuav kom ua pov thawj tias spermidine tuaj yeem tswj cov noob caj noob ces uas cuam tshuam nrog kev puas tsuaj ntawm cov protein, pab pawg tshawb fawb tau pom 181 noob caj noob ces uas raug tswj hwm qis dua thiab 82 noob caj noob ces uas raug tswj hwm los ntawm kev tshawb pom cov hlwb uas tau kho nrog spermidine, tsis suav nrog cov noob caj noob ces uas cuam tshuam nrog melanogenesis. Txhawm rau ua pov thawj ntxiv, pab pawg tshawb fawb tau tshuaj xyuas qhov cuam tshuam ntawm spermidine rau qib kev qhia tawm ntawm tyrosinase gene tsev neeg TYR, TRP-1 thiab TRP-2, uas yog cov noob caj noob ces uas tswj hwm kev tsim melanin. Qib kev qhia tawm mRNA tau lees paub tias spermidine tsis hloov pauv qhov kev qhia tawm ntawm cov noob caj noob ces uas cuam tshuam nrog melanogenesis. Txawm li cas los xij, kev ua haujlwm ntawm ntau cov noob caj noob ces raug hloov pauv los ntawm spermidine thiab cuam tshuam nrog kev puas tsuaj ntawm cov protein. Ntau cov noob caj noob ces uas hloov pauv muaj feem cuam tshuam nrog ubiquity, uas yog lub kaw lus puas tsuaj ntawm cov protein uas cuam tshuam nrog melanogenesis.
3. Spermidine tswj kev ruaj khov ntawm cov protein thiab txhawb nqa melanin ntau lawm.
Kev tsim cov melanin yog tswj hwm los ntawm qhov sib npaug ntawm kev tsim thiab kev puas tsuaj ntawm cov protein cuam tshuam nrog melanin. Spermidine kho TYR, TRP-1 thiab TRP-2 noob. Los ntawm kev ua haujlwm ntawm cov noob thauj khoom SLC3A2, SLC7A1, SLC18B1 thiab SLC22A18, nws tuaj yeem ua rau kom muaj cov polyamines hauv cov hlwb, yog li ua rau kom muaj kev ruaj khov ntawm cov protein cuam tshuam nrog melanin ntau lawm los txhawb kev tsim melanin hauv vivo.
Xaus lus, txoj kev tshawb fawb no qhia tau hais tias cov tshuaj spermidine ntuj muaj lub luag haujlwm tseem ceeb hauv kev kho mob hypopigmentation, thiab muaj qee yam txiaj ntsig ntawm kev siv hauv kev kho kom zoo nkauj thiab cov khoom noj qab haus huv yav tom ntej.
Siv rau:
[1].Brito, S., Heo, H., Cha, B. et al. Ib qho kev tshawb nrhiav tsis tu ncua qhia txog lub peev xwm ntawm spermidine rau kev kho mob hypopigmentation los ntawm kev ruaj khov ntawm cov protein cuam tshuam nrog melanogenesis.Sci Rep 12, 14478 (2022). https://doi.org/10.1038/s41598-022-18629-3.
Lub sijhawm tshaj tawm: Cuaj hlis-28-2022