β-Nicotinamide adenine dinucleotide (acid dawb) (NAD)
NAD yog ib qho coenzyme ntawm dehydrogenase uas muaj ntau heev hauv cov tsiaj txhu uas muaj sia nyob. Nws koom nrog cov tshuaj redox hauv cov tsiaj txhu uas muaj sia nyob, thiab thauj thiab hloov cov electrons rau cov tshuaj hauv cov tshuaj. Dehydrogenase ua lub luag haujlwm tseem ceeb hauv tib neeg lub cev metabolism. Qee qhov kev txav mus los yooj yim ntawm tib neeg lub cev, xws li protein decomposition, carbohydrate decomposition, thiab rog decomposition, tsis tuaj yeem ua tiav ib txwm yam tsis muaj dehydrogenase, thiab tib neeg yuav poob cov cim tseem ceeb. Thiab vim tias kev sib xyaw ua ke ntawm NAD thiab dehydrogenase tuaj yeem txhawb kev metabolism, yog li NAD yog ib feem tseem ceeb ntawm tib neeg lub cev. Raws li kev siv khoom, nws tuaj yeem faib ua cov qib hauv qab no: biotransformation qib, kuaj mob reagent qib, zaub mov noj qab haus huv qib, API thiab npaj cov khoom siv raw.
| Lub Npe Tshuaj | Nicotinamide adenine dinucleotide (cov kua qaub dawb) |
| Cov lus txhais | β-Nicotinamide adenine dinucleotide |
| Tus lej CAS | 53-84-9 |
| Qhov Hnyav Molecular | 663.43 |
| Cov Qauv Molecular | C21H27N7O14P2 |
| EINECS: | 200-184-4 |
| Qhov kub yaj | 140-142 ° C (decomp) |
| cia kub. | -20°C |
| kev yaj tau | H2O: 50 mg/mL |
| daim ntawv | Hmoov |
| xim | Dawb |
| Merck | 14,6344 |
| BRN | 3584133 |
| Kev Ruaj Ntseg: | Ruaj khov. Hygroscopic. Tsis sib haum nrog cov neeg sawv cev oxidizing muaj zog. |
| InChIKey | BAWFJGJZGIEFAR-WWRWIPRPSA-N |
| Khoom Siv Kuaj | Cov Lus Qhia Tshwj Xeeb |
| Qhov tsos | Dawb rau cov hmoov crystalline dawb |
| Kev tshuaj xyuas UV spectral εntawm 260 nm thiab pH 7.5 | (18±1.0) × 10³ L/mol/cm3 |
| Kev yaj tau | 25mg/mL 25mg/mL hauv dej |
| Cov Ntsiab Lus (los ntawm kev tshuaj xyuas enzymatic nrog ADH ntawm pH 10, siv spectrophotometer, abs.340nm, ntawm anhydrous) | ≥98.0% |
| Kev Ntsuas (los ntawm HPLC, ntawm anhydrous hauv paus) | 98.0~102.0% |
| Kev huv (los ntawm HPLC,% cheeb tsam) | ≥99.0% |
| Cov dej hauv (los ntawm KF) | ≤3% |
Pob:Lub raj mis, Lub hnab ntawv txhuas, 25kg / Cardboard nruas, lossis raws li tus neeg siv khoom xav tau.
Kev Khaws Cia:Khaws cia kom nruj rau hauv qhov tsaus ntuj, khaws cia rau ntawm 2 ~ 8 ℃ rau lub sijhawm ntev.
Qib Biotransformation: Nws tuaj yeem siv rau kev tsim cov tshuaj intermediates thiab APIs, feem ntau nrog cov enzymes catalytic, xws li ketoreductase (KRED), nitroreductase (NTR), P450 monooxygenase (CYP), formate dehydrogenase (FDH)), glucose dehydrogenase (GDH), thiab lwm yam, uas tuaj yeem koom tes los hloov ntau yam amino acid intermediates thiab lwm yam tshuaj cuam tshuam. Tam sim no, ntau lub Hoobkas tshuaj hauv tsev tau pib siv cov enzyme hloov pauv biological, thiab kev thov ua lag luam rau NAD + tab tom loj hlob sai.
Qib tshuaj reagent kuaj mob: Ua ke nrog ntau yam tshuaj enzymes kuaj mob, ua cov khoom siv raw ntawm cov khoom siv kuaj mob.
Qib khoom noj khoom haus kev noj qab haus huv: NAD yog ib qho coenzyme ntawm dehydrogenase. Nws ua lub luag haujlwm tseem ceeb hauv glycolysis, gluconeogenesis, lub voj voog tricarboxylic acid, thiab txoj hlab pa, ua lub luag haujlwm tseem ceeb hauv kev tsim hluav taws xob, thiab pab tsim L-dopa, uas dhau los ua dopamine Neurotransmitters. Tshwj xeeb tshaj yog nyob rau xyoo tas los no, nws tau pom tias nws yog "cav" thiab "roj" hauv cov txheej txheem ntawm kev kho cov hlwb puas tsuaj. Raws li kev tshawb fawb, kev ntxiv ntawm coenzymes (suav nrog NMN, NR, NAD, NADH) hauv vitro tuaj yeem txhim kho lub peev xwm antioxidant ntawm cov hlwb nqaij, tiv thaiv apoptosis signaling, rov qab ua haujlwm ntawm cov hlwb ib txwm muaj, tiv thaiv kev tshwm sim ntawm kab mob lossis tiv thaiv kev loj hlob ntawm kab mob.
Ntxiv rau, coenzymes tuaj yeem txhim kho lub peev xwm ntawm kev tiv thaiv kab mob los ntawm kev ua kom muaj zog thiab txhawb kev loj hlob ntawm cov hlwb tiv thaiv kab mob, tsim cov tshuaj tiv thaiv kev o thiab txo cov hlwb T. Nicotinamide dinucleotide oxidation state (NAD +) yog ib qho coenzyme pom muaj nyob rau hauv txhua lub hlwb uas muaj sia nyob. Nws ua lub luag haujlwm tseem ceeb hauv ntau pua txoj kev ua haujlwm hauv cov hlwb, koom nrog ntau txhiab qhov kev cuam tshuam ntawm lub cev, thiab yog tus tswv cuab tseem ceeb tshaj plaws ntawm cov saw hlau thauj hluav taws xob. Hydrogen pub; tib lub sijhawm, coenzyme I ua haujlwm ua lub hauv paus ntawm cov enzymes cuam tshuam hauv lub cev, pab tswj cov haujlwm ntawm cov enzymes.
Nicotinamide mononucleotide (NMN) yog cov khoom sib xyaw ua ntej ntawm nicotinamide adenine dinucleotide oxidation state (NAD+), uas koom nrog kev tsim NAD hauv vivo. Xyoo 2013, Xibfwb David Sinclair ntawm Harvard Medical School pom tias nrog hnub nyoog, qib cofactor coenzyme I (NAD+) ntawm cov protein ntev hauv lub cev txuas ntxiv poob qis, uas ua rau kev poob qis ntawm mitochondrial kev ua haujlwm ntawm lub cell "dynamo", ua rau kev laus, thiab ntau yam hauv lub cev. Yog li ntawd, qhov ua haujlwm tsis zoo ntawm hom kev ua haujlwm no tau tsim tawm. Raws li nws cov kev tshawb fawb, cov ntsiab lus ntawm NAD+ hauv lub cev tib neeg txo qis nrog hnub nyoog, ua rau kev laus sai dua txij li hnub nyoog 30 xyoo, nrog rau wrinkles, so cov leeg, rog sib sau ua ke, thiab cov kab mob xws li kab mob plawv, ntshav siab, mob stroke, ntshav qab zib thiab kab mob Alzheimer's ua rau muaj kev pheej hmoo ntau ntxiv. Qhov tseem ceeb rau kev ntev yog kom nce qib ntawm coenzyme I (NAD+) hauv lub cev, nce tus nqi ntawm cov metabolism ntawm lub cell, thiab txhawb nqa lub zog hluas.
API thiab cov khoom siv raw rau kev npaj: NAD + siv rau hauv kev txhaj tshuaj rau kev kho mob / tswj kev quav yeeb quav tshuaj, suav nrog NAD IV kev kho mob intravenous uas tau siv hauv Tebchaws Meskas, Tebchaws Europe, Russia, South Africa, Mexico, South America, Southeast Asia thiab lwm lub tebchaws. Cov khoom lag luam uas tau npaj los ntawm tsev muag tshuaj, zoo ib yam li cov tsev muag tshuaj Asmeskas, tuaj yeem yuav cov khoom siv raw rau kev faib tshuaj los ntawm lawv tus kheej, ib yam li cov khoom siv hauv tsev kho mob Suav, nws tswj qhov zoo ntawm cov khoom siv raw los ntawm nws tus kheej, thiab npaj cov khoom siv rau hauv cov tshuaj.
