β-Nicotinamide adenine dinucleotide (dawb acid) (NAD)
NAD yog ib qho coenzyme ntau heev ntawm dehydrogenase hauv cov kab mob muaj sia.Nws koom nrog cov tshuaj tiv thaiv redox hauv cov kab mob muaj sia, thiab thauj thiab hloov hluav taws xob rau cov tshuaj hauv cov tshuaj tiv thaiv.Dehydrogenase plays lub luag haujlwm txiav txim siab hauv tib neeg cov metabolism.Qee qhov yooj yim metabolic txav ntawm tib neeg lub cev, xws li protein decomposition, carbohydrate decomposition, thiab rog decomposition, tsis tuaj yeem nqa tawm ib txwm tsis muaj dehydrogenase, thiab tib neeg yuav poob cov cim tseem ceeb.Thiab vim tias kev sib xyaw ntawm NAD thiab dehydrogenase tuaj yeem txhawb cov metabolism, yog li NAD yog ib feem tseem ceeb ntawm tib neeg lub cev.Raws li cov khoom siv, nws tuaj yeem muab faib ua cov qib hauv qab no: qib biotransformation, qib kuaj tshuaj reagent, qib zaub mov noj qab haus huv, API thiab cov khoom siv raw.
| Tshuaj npe | Nicotinamide adenine dinucleotide (dawb acid) |
| Synonyms | β-Nicotinamide adenine dinucleotide |
| CAS Nr | 53-84-9 : kuv |
| Molecular Luj | 663.43 ib |
| Molecular Formula | C21H27N7O14P2 |
| EINECS: | 200-184-4 ib |
| Melting point | 140-142 ° C (decomp) |
| cia temp. | -20 ° C |
| solubility | H2O: 50 mg/ml |
| daim ntawv | Hmoov |
| xim | Dawb |
| Merck | 14, 6344 ib |
| BRN | 3584133 ib |
| Kev ruaj ntseg: | ruaj khov.Hygroscopic.Incompatible nrog muaj zog oxidizing neeg sawv cev. |
| InChIKey | BAWFJGJZGIEFAR-WWRWIPRPSA-N |
| Cov khoom kuaj | Specifications |
| Qhov tshwm sim | Dawb mus rau dawb crystalline hmoov |
| UV spectral tsom xam εntawm 260 nm thiab pH 7.5 | (18 ± 1.0) × 10³ L/mol/cm |
| Solubility | 25mg / ml 25mg / ml hauv dej |
| Cov ntsiab lus (los ntawm kev txheeb xyuas enzymatic nrog ADH ntawm pH 10, siv spectrophotometer, abs.340nm, ntawm cov dej tsis muaj dej) | ≥98.0% |
| Assay (los ntawm HPLC, raws li tsis muaj dej) | 98.0 ~ 102.0% |
| Purity (los ntawm HPLC,% cheeb tsam) | ≥99.0% |
| Cov ntsiab lus dej (los ntawm KF) | ≤ 3% |
Pob:Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, los yog raws li tus neeg yuav tsum tau muaj.
Cia txias:Khaws nruj nreem kaw rau hauv qhov tsaus ntuj, kom ntev cia cia ntawm 2 ~ 8 ℃.
Biotransformation qib: Nws tuaj yeem siv rau biocatalytic synthesis ntawm kws tshuaj intermediates thiab APIs, feem ntau nrog catalytic enzymes, xws li ketoreductase (KRED), nitroreductase (NTR), P450 monooxygenase (CYP), formate dehydrogenase (FDH) ), qabzib dehydrogenase ( GDH), thiab lwm yam., uas tuaj yeem koom tes los hloov ntau yam amino acid intermediates thiab lwm yam tshuaj.Tam sim no, ntau lub tsev muag tshuaj hauv tsev tau pib siv cov tshuaj lom neeg hloov pauv, thiab kev lag luam xav tau rau NAD + tau loj hlob sai.
Diagnostic reagent qib: Ua ke nrog ntau yam kev kuaj mob enzymes, raws li raw khoom ntawm cov khoom siv kuaj mob.
Kev noj qab haus huv qib: NAD yog coenzyme ntawm dehydrogenase.Nws ua lub luag haujlwm tsis tuaj yeem hloov pauv hauv glycolysis, gluconeogenesis, lub voj voog tricarboxylic acid, thiab cov kab mob ua pa, ua lub luag haujlwm tseem ceeb hauv kev tsim hluav taws xob, thiab pab tsim L-dopa, uas dhau los ua dopamine Neurotransmitters.Tshwj xeeb tshaj yog nyob rau hauv xyoo tas los no, nws tau pom tias nws yog "lub cav" thiab "roj" nyob rau hauv cov txheej txheem ntawm kev puas tsuaj ntawm tes.Raws li kev tshawb fawb, kev ntxiv ntawm coenzymes (xws li NMN, NR, NAD, NADH) hauv vitro tuaj yeem txhim kho cov antioxidant muaj peev xwm ntawm cov ntaub so ntswg, inhibit apoptosis signaling, rov ua haujlwm ntawm tes, tiv thaiv kab mob tshwm sim lossis cuam tshuam cov kab mob.
Tsis tas li ntawd, coenzymes tuaj yeem txhim kho lub peev xwm ntawm lub cev tiv thaiv kab mob los ntawm kev ua kom muaj zog thiab txhawb kev loj hlob ntawm lub cev tiv thaiv kab mob hauv lub cev, tsim cov tshuaj tiv thaiv kab mob thiab tiv thaiv kev tswj T hlwb.Nws ua lub luag haujlwm tseem ceeb hauv ntau pua cov txheej txheem metabolic hauv cov hlwb, koom nrog ntau txhiab qhov kev xav ntawm lub cev, thiab yog tus tswv cuab tseem ceeb tshaj plaws ntawm cov saw hlau thauj khoom.Hydrogen pub;Nyob rau tib lub sijhawm, coenzyme I ua raws li ib qho substrate ntawm cov enzymes cuam tshuam hauv lub cev, pab tswj kev ua haujlwm ntawm cov enzymes.
Nicotinamide mononucleotide (NMN) yog qhov sib xyaw ua ntej ntawm nicotinamide adenine dinucleotide oxidation xeev (NAD +), uas koom nrog hauv kev sib txuas ntawm NAD hauv vivo.Xyoo 2013, xibfwb David Sinclair ntawm Harvard Medical School pom tias nrog lub hnub nyoog, cofactor coenzyme I (NAD +) qib ntawm cov protein nyob rau hauv lub cev ntev mus txuas ntxiv, uas ua rau kev poob qis ntawm mitochondrial kev ua haujlwm ntawm lub xovtooj ntawm "dynamo", ua rau kev laus. , thiab ntau yam hauv lub cev.Lub malfunction ntawm hom kev ua no yog li tsim.Raws li nws cov kev tshawb fawb, cov ntsiab lus ntawm NAD + hauv tib neeg lub cev poob qis nrog lub hnub nyoog, ua rau muaj kev laus zuj zus los ntawm hnub nyoog 30 xyoo, nrog rau wrinkles, nqaij so, rog, thiab kab mob xws li mob plawv, ntshav siab, mob stroke. , ntshav qab zib thiab Alzheimer's kab mob ua rau muaj kev pheej hmoo ntau ntxiv.Tus yuam sij rau kev ua neej nyob ntev yog nce qib ntawm coenzyme I (NAD +) hauv lub cev, nce tus nqi ntawm cov cell metabolism, thiab txhawb cov tub ntxhais hluas lub zog.
API thiab kev npaj raw cov ntaub ntawv: NAD + yog siv rau hauv kev txhaj tshuaj rau kev kho / tswj kev quav yeeb tshuaj, suav nrog NAD IV txoj kev kho cov hlab ntsha siv hauv Tebchaws Meskas, Europe, Russia, South Africa, Mexico, South America, Southeast Asia thiab lwm lub tebchaws.Cov khoom lag luam npaj rau nws tus kheej, zoo ib yam li cov khw muag tshuaj Asmeskas, tuaj yeem yuav cov khoom siv raw rau kev xa tawm los ntawm lawv tus kheej, ib yam li kev npaj hauv tsev kho mob hauv Suav teb, nws tswj hwm cov khoom zoo ntawm nws tus kheej, thiab npaj cov tshuaj npaj.
