Bet-Nicotinamide Mononucleotide (NMN)
Tsis ntev los no, muaj xov xwm zoo hauv NMN - tom qab kev tshuaj xyuas nruj los ntawm pawg kws tshaj lij ntawm US Food and Drug Administration (FDA) lub koom haum tso cai, NMN raw khoom ntawm Shangke Biopharmaceutical (Shanghai) Co., Ltd. raws li "Shangke Bio") tau txais kev pom zoo los ntawm Tebchaws Meskas FDA NDI kev pom zoo lees paub tias nws cov khoom siv NMN tuaj yeem raug siv hauv kev tsim, muag thiab kev txhawb nqa cov khoom noj khoom haus hauv Tebchaws Meskas, thiab tuaj yeem nrhiav tau ntawm FDA official lub vev xaib raws li cov khoom noj khoom haus tshiab tshiab, tus lej 1247.
FDA NDI yog cov ntawv pov thawj tseem ceeb tshaj plaws hauv Asmeskas kev lag luam.Tau txais daim ntawv pov thawj no tsis tsuas yog txhais tau tias kev nyab xeeb thiab zoo ntawm Shangke Bio cov khoom yogtau txais kev lees paub zoo, tab sis kuj yog qhov tsim nyog rau kev txhim kho tus qauv txuas ntxiv ntawm NMN kev lag luam hauv lub sijhawm ntev.
| Tshuaj npe | β-Nicotinamide Mononucleotide |
| Synonyms | NICOTINAMIDE-1-IUM-1-BETA-D-RIBOFURANOSID 5'-PHOSPHATE |
| CAS Nr | 1094-61-7 ib |
| Molecular Luj | 334.22 ib |
| Molecular Formula | C11H15N2O8P |
| EINECS: | 214-136-5 : kuv |
| Melting point | 166 ° C (txog.) |
| cia temp. | -20 ° C |
| solubility | DMSO (me ntsis, rhaub), Methanol (me ntsis), Dej (me ntsis) |
| daim ntawv | Khoom |
| xim | Dawb rau daj |
| Merck | 13, 6697 ib |
| BRN | 3570187 ib |
| Kev ruaj ntseg: | Hygroscopic heev |
| InChIKey | DAYLJWODMCOQEW-TURQNECASA-N |
| Cov khoom kuaj | Specifications |
| Qhov tshwm sim | Dawb mus rau dawb crystalline hmoov |
| Cov ntsiab lus sodium | ≤ 1% |
| pH tus nqi (100mg / ml) | 2.0 ~ 4.0 |
| Purity | ≥99.0% |
| Cov ntsiab lus dej | ≤ 1% |
| Cov hlau hnyav | <10ppm |
| Arsenic | <0.5ppm |
| Coj | <0.5ppm |
| Mercury | <0.1ppm |
| Cadmium | <0.5ppm |
| Solvent residue | Ethanol ≤1000ppm |
| Tag nrho Aerobic Microbial suav | <750cfu/g |
| Poov & Pwm | <25cfu/g |
| Tag nrho cov coliform | ≤0.92MPN / g |
| E. Coli | Tsis zoo |
| Salmonella | Tsis zoo |
| Staph.Aureus | Tsis zoo |
| Assay (raws li anhydrous hauv paus) | ≥99.0% |
| Sieving tus nqi | ≥95% |
| Qhov ntom ntom | Qhia kom paub |
Pob:Lub raj mis, Aluminium ntawv ci hnab, 25kg / Cardboard Nruas, los yog raws li tus neeg yuav tsum tau muaj.
Cia txias:Khaws nyob rau hauv nruj, lub teeb-resistant ntim, rau lub sij hawm cia cia ntawm 2 ~ 8 ° C los yog qis dua.
Nicotinamide Mononucleotide (NMN) yog ib qho tshiab ntawm vitamin B3 uas yog 1 kauj ruam ua ntej rau NAD + (Nicotinamide Adenine Dinucleotide).NMN yog thawj cellular NAD + restorer los ua pov thawj zoo los kho cov hlwb hauv vivo.
Nicotinamide Adenine Dinucleotide (NAD) yog ib qho tseem ceeb tshaj plaws thiab nthuav molecules hauv lub cev.Nws yuav tsum muaj ntau tshaj 500 enzymatic cov tshuaj tiv thaiv thiab ua lub luag haujlwm tseem ceeb hauv kev tswj hwm ntawm yuav luag tag nrho cov txheej txheem lom neeg loj (Ansari thiab Raghava, 2010).Qhov tseem ceeb tshaj, nws tuaj yeem tso cai rau peb coj noj qab haus huv thiab muaj sia nyob ntev.
Nicotinamide Adenine Dinucleotide (NAD) muaj nyob rau hauv nws daim ntawv oxidized (NAD +) los yog txo daim ntawv (NADH), uas yog ib qho tseem ceeb cofactors ntawm ib tug xov tooj ntawm oxireductases.
SyncoZyems yog thawj tus tau txais FDA NDI NMN pom zoo cov khoom siv raw khoom lag luam, sawv cev rau FDA cov neeg ua haujlwm lees txais NMN raws li cov khoom siv tshiab tuaj yeem pib txais thiab pom zoo rau cov khoom noj khoom haus ntxiv hauv Tebchaws Meskas.
