Nicotinamide adenine dinucleotide (NAD+) yog qhov chaw tshawb fawb ntawm cov kws tshawb fawb hauv tsev thiab txawv teb chaws. Feem ntau cov kws tshawb fawb ntseeg tias qib NAD+ muaj feem cuam tshuam nrog cov kab mob ntev uas cuam tshuam nrog hnub nyoog, xws li mob qog noj ntshav, rog dhau, ntshav siab thiab ntshav qab zib.
Kab mob Keratinocyte carcinoma (KC) yog hom mob qog nqaij hlav uas feem ntau tshwm sim rau cov neeg tawv dawb, suav nrog basal cell carcinoma (BCC) thiab squamous cell carcinoma (cSCC). Tsis ntev los no, cov kws tshawb fawb Asmeskas tau luam tawm tsab xov xwm sib tham hauv J DRUGS DERMATOL txog kev ntxiv NAD precursors NMN thiab NR kom txo qhov kev pheej hmoo ntawm mob qog nqaij hlav keratinocyte.
Tus sau ntawv xav tias nicotinamide (NAM), ua tus ua ntej ntawm NAD +, tau raug pov thawj los ntawm Choy B thiab lwm tus kws tshawb fawb los txo qhov tshwm sim ntawm mob qog nqaij hlav keratinocyte. Txawm li cas los xij, nicotinamide mononucleotide (NMN) thiab nicotinamide nucleoside (NR), uas kuj yog cov ua ntej ntawm NAD + synthesis, tej zaum yuav yog cov tshuaj ntxiv zoo dua los txo qhov tshwm sim ntawm mob qog nqaij hlav keratinocyte.
Kev noj NMN thiab NR hauv qhov ncauj tuaj yeem ua rau NAD + nce ntxiv.
Xyoo 2018, Sinclair DA thiab lwm cov kws tshawb fawb tau ua pov thawj tias piv rau NAM, kev noj NMN thiab NR los kho tib neeg thiab nas ua rau NAD + ntau ntxiv hauv cov ntshav thiab daim siab, raws li. Yog li ntawd, NMN thiab NR tau tsim NAD + zoo dua.
NMN thiab NR muaj kev nyab xeeb thiab zoo dua rau kev noj qab haus huv
Cov tshuaj NMN thiab NR tau siv dav hauv tib neeg thiab tsiaj txhu, thiab tsis muaj kev lom lossis cov kev mob tshwm sim loj heev tau tshaj tawm txog tam sim no. Ib txoj kev tshawb fawb hauv 25 tus poj niam premenopausal uas muaj pre-diabetes tau noj NMN ntxiv ntawm qhov koob tshuaj ntawm 250 mg / hnub, thiab pom tias NMN ua rau cov leeg nqaij insulin rhiab heev yam tsis ua rau muaj kev phiv. Txoj kev tshawb fawb thib ob tau tsom mus rau qhov cuam tshuam ntawm NMN ntxiv rau cov neeg khiav lub peev xwm aerobic. Peb caug rau tus neeg koom nrog tau txais 300 mg / hnub (n = 12), 600 mg / hnub (n = 12) lossis 1200 mg / hnub (n = 12) NMN, thiab tsis muaj kev phiv lossis cov kev mob tshwm sim tsis zoo tau tshaj tawm. Txawm hais tias US Food and Drug Administration (FDA) tseem tsis tau pom zoo ob yam khoom xyaw no rau cov khoom noj khoom haus ntxiv, NMN thiab NR ntxiv tuaj yeem yuav tau yooj yim online, thiab ntau tus neeg siv khoom tau pib noj lawv, nrog rau cov koob tshuaj txij li 500mg txog 1000mg / hnub. Tsis muaj kev mob tshwm sim tsis zoo tau pom.
Piv nrog NAM, NMN thiab NR uas noj tuaj yeem ua rau NAD+ theem nce ntxiv zoo dua thiab muaj kev nyab xeeb thiab kev kam rau siab dua, uas yog ib txoj kev kho mob zoo rau cov kws kho mob tawv nqaij kom txo qhov kev pheej hmoo ntawm mob qog nqaij hlav keratinocyte. Txawm li cas los xij, nws tseem xav tau ntau cov ntaub ntawv tshawb fawb hauv tsev kho mob kom paub tseeb tias nws siv tau rau hauv kev kho mob hauv tsev kho mob.
Cov ntaub ntawv siv los ua piv txwv:
[1]. Kahn B, Borrelli M, Libby T. Kev Tshuaj Xyuas Zaj Dab Neeg ntawm Nicotinamide Adenine Dinucleotide (NAD) + Intermediates Nicotinamide Riboside thiab Nicotinamide Mononucleotide rau Kev Txo Kev Pheej Hmoo Keratinocyte Carcinoma. J Drugs Dermatol. 2022 Lub Kaum Hli 1; 21 (10): 1129-1132. doi: 10.36849 / JDD.6870. PMID: 36219044.
Lub sijhawm tshaj tawm: Lub Kaum Hli-25-2022