Kev ua kom macrophage ua haujlwm yog ib qho txheej txheem pathogenic ua rau muaj kev o tuaj yeem ua rau lub cev mob ntev, tab sis kev ua kom macrophage ua haujlwm tas li tuaj yeem ua rau mob ntev thiab cov kab mob xws li kev tsis kam insulin thiab cov kab mob hnyav xws li atherosclerosis. PGE 2, uas yog tus neeg sawv cev rau kev teb rau kev o, yog tsim los ntawm arachidonic acid los ntawm cyclooxygenases (COX-1 thiab COX-2). COX-1 thiab COX-2 yog cov hom phiaj tseem ceeb ntawm kev tiv thaiv kev o thiab tuaj yeem raug txwv los ntawm cov tshuaj tiv thaiv kev o uas tsis yog steroidal (NSAIDs).
Kev siv cov tshuaj NSAIDs tuaj yeem ua rau muaj ntau yam kev tsis zoo, xws li kev los ntshav hauv plab hnyuv. Yog li ntawd, nws yog ib qho tseem ceeb heev uas yuav tsum nrhiav cov tshuaj ntuj uas muaj kev nyab xeeb dua los kho qhov o.
Tsis ntev los no, pab pawg tshawb fawb los ntawm Tsinghua University tau kho cov nas macrophages nrog NMN, thiab ua pov thawj los ntawm kev sim tias NMN tuaj yeem txo qhov kev sib sau ua ke ntawm cov protein cuam tshuam nrog kev o thiab cov khoom lag luam metabolic, thiab tiv thaiv kev teb o ntawm macrophages. Cov ciam teb hauv Molecular Biosciences.
Kev o hloov pauv cov theem ntawm cov khoom lag luam metabolic hauv macrophages
Ua ntej, pab pawg tshawb fawb tau ua kom cov macrophages ua haujlwm los tsim kev o los ntawm lipopolysaccharide (LPS), thiab tom qab ntawd tau tshuaj xyuas cov ntsiab lus ntawm cov khoom lag luam nyob ib puag ncig macrophages thaum lub sijhawm o. Cov theem ntawm 99 metabolites tau nce thiab 105 metabolites tau txo qis ntawm 458 molecules uas tau pom ua ntej thiab tom qab kev txhawb nqa kev o, thiab NAD + theem uas nrog kev o kuj tau txo qis.
(DUAB 1)
NMN ua rau NAD ntau ntxiv thiab txo qhov mob ntawm cov macrophage
Cov pab pawg tshawb fawb tom qab ntawd tau kho cov macrophages nrog LPS, uas ua rau muaj kev mob o, IL-6 thiab IL-1β, cov cytokines pro-inflammatory uas ua raws li cov cim ntawm kev mob o. Tom qab NMN kho LPS-induced macrophage o, nws tau pom tias qib intracellular NAD tau nce thiab mRNA kev qhia ntawm IL-6 thiab IL-1β tau txo qis. Cov kev sim tau qhia tias NMN ua rau qib ntawm NAD nce thiab txo qis LPS-induced macrophage o.
(Daim Duab 2)
(Daim Duab 3)
NMN txo cov protein uas cuam tshuam nrog kev o
Kev kho mob NMN, nws pom tias cov protein cuam tshuam nrog kev o xws li RELL1, PTGS2, FGA, FGB thiab igkv12-44 tau txo qis hauv cov hlwb, uas qhia tau tias NMN txo qhov kev qhia tawm ntawm cov protein cuam tshuam nrog kev o.
(Daim Duab 4)
NMN txo qhov kev qhia tawm ntawm NSAIDS cov protein target
Qhov kev sim zaum kawg pom tias NMN txo cov theem ntawm PGE2 hauv LPS-activated RAW264.7 hlwb los ntawm kev txo cov qib kev qhia tawm ntawm COX-2, yog li txo cov kev qhia tawm ntawm COX2 thiab inhibiting LPS-induced o.
(Daim Duab 6)
xaus lus, kev ntxiv NMN tuaj yeem kho tau qhov mob o hauv nas, thiab kev kho mob o hauv tib neeg tseem yuav tsum tau txheeb xyuas los ntawm kev sim tshuaj. Tej zaum NMN yuav dhau los ua ib qho hloov rau NSAIDS yav tom ntej.
cov ntaub ntawv siv:
1.Liu J, Zong Z, Zhang W, Chen Y, Wang X, Shen J, Yang C, Liu X, Deng H. Nicotinamide Mononucleotide Alleviates LPS-Induced Inflammation thiab Oxidative Stress ntawm Txo COX-2 Qhia hauv Macrophages. Pem Hauv Ntej Mol Biosci. 2021 Peb 6.
Lub sijhawm tshaj tawm: Kaum Ib Hlis-26-2022