Kev ua kom Macrophage yog ib txoj hauv kev ua rau cov kab mob ua rau mob ntev hauv lub cev, tab sis kev ua kom macrophage tsis tu ncua tuaj yeem ua rau mob ntev thiab kab mob xws li insulin tsis kam thiab kab mob hnyav xws li atherosclerosis.PGE 2, uas kho cov lus teb inflammatory, yog tsim los ntawm arachidonic acid los ntawm cyclooxygenases (COX-1 thiab COX-2).COX-1 thiab COX-2 yog lub hom phiaj tseem ceeb ntawm kev tiv thaiv kab mob thiab tuaj yeem cuam tshuam los ntawm cov tshuaj uas tsis yog steroidal anti-inflammatory (NSAIDs).
Kev siv NSAIDs tuaj yeem ua rau muaj ntau yam tsis zoo, xws li los ntshav hauv plab .Yog li ntawd, nws yog ib qho tseem ceeb tshwj xeeb los nrhiav cov khoom muaj txiaj ntsig zoo los kho qhov mob.
Tsis ntev los no, ib pab neeg tshawb fawb los ntawm Tsinghua University tau kho nas macrophages nrog NMN, thiab tau ua pov thawj los ntawm kev sim uas NMN tuaj yeem txo qis kev sib txuam ntawm cov kab mob ntsig txog cov protein thiab metabolic byproducts, thiab inhibit qhov inflammatory teb ntawm macrophages.Frontiers hauv Molecular Biosciences.
Kev ua xua hloov cov theem ntawm cov khoom siv hauv metabolic hauv macrophages
Ua ntej, pab pawg tshawb fawb tau qhib cov macrophages los tsim qhov mob los ntawm lipopolysaccharide (LPS), thiab tom qab ntawd txheeb xyuas cov ntsiab lus ntawm cov khoom lag luam nyob ib puag ncig macrophages thaum lub sijhawm mob.Cov qib ntawm 99 metabolites tau nce thiab 105 metabolites tau txo qis ntawm 458 molecules kuaj pom ua ntej thiab tom qab inflammatory stimulation, thiab NAD + qib uas nrog rau qhov mob kuj tau txo.
(Daim duab 1)
NMN nce qib NAD thiab txo cov mob macrophage
Pab pawg tshawb fawb tom qab ntawd kho cov macrophages nrog LPS, uas ua rau muaj kev mob tshwm sim, IL-6 thiab IL-1β, pro-inflammatory cytokines uas ua raws li cov cim ntawm o.Tom qab NMN kev kho mob ntawm LPS-induced macrophage o, nws tau pom tias qib intracellular NAD tau nce thiab mRNA qhia ntawm IL-6 thiab IL-1β tau txo qis.Cov kev sim tau pom tias NMN nce qib ntawm NAD thiab txo qis LPS-induced macrophage o.
(Daim duab 2)
(Daim duab 3)
NMN txo qis cov protein uas muaj feem cuam tshuam rau qhov mob
NMN kev kho mob, nws tau pom tias cov proteins uas cuam tshuam txog kev mob xws li RELL1, PTGS2, FGA, FGB thiab igkv12-44 tau txo qis hauv cov hlwb, uas qhia tias NMN txo cov kev qhia ntawm cov kab mob ntsig txog cov protein.
(Daim duab 4)
NMN txo qhov kev qhia ntawm NSAIDS lub hom phiaj cov proteins
Qhov kev sim zaum kawg pom tau tias NMN txo qis PGE2 hauv LPS-activated RAW264.7 hlwb los ntawm kev txo qis theem ntawm COX-2, yog li txo qhov kev qhia ntawm COX2 thiab inhibiting LPS-induced o.
(Daim duab 6)
Kev txiav txim siab, kev ntxiv ntawm NMN tuaj yeem kho cov kab mob ntev ntev hauv cov nas, thiab kev kho mob ntawm tib neeg tseem yuav tsum tau txheeb xyuas los ntawm cov kev sim tshuaj cuam tshuam.Tej zaum NMN yuav dhau los ua qhov hloov pauv rau NSAIDS yav tom ntej.
cov ntaub ntawv:
1.Liu J, Zong Z, Zhang W, Chen Y, Wang X, Shen J, Yang C, Liu X, Deng H. Nicotinamide Mononucleotide Alleviates LPS-Induced Inflammation and Oxidative Stress of Decreasing COX-2 Expression in Macrophages.Pem Hauv Ntej Mol Biosci.2021 Peb 6.
Post lub sij hawm: Nov-26-2022