Nitrile hydratase (NHT) hmoov
Lus piav qhia luv luv:
Hais txog ES-NHTs
ES-NHTs: ib chav kawm ntawm metalloenzyme, uas xaiv hydrate nitriles rau hauv cov thawj amide.Lawv tau dav siv tsis tau tsuas yog rau cov synthesis ntawm amino acids, amides, carboxylic acids thiab lawv derivatives, tab sis kuj rau kev npaj ntawm chiral tshuaj.Muaj 24 hom nitrile hydratases tsim los ntawm SyncoZymes (Tswj raws li ES-NHT-101～ES-NHT-124).
Catalytic tshuaj tiv thaiv hom:
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| Enzymes | Khoom Code | Specification |
| Enzyme hmoov | ES-NHT-101 ~ ES-NHT-124 | ib txheej ntawm 24 Nitrile Hydratases, 50 mg txhua 24 yam khoom * 50mg / khoom, lossis lwm yam kom muaj nuj nqis |
| Cov khoom siv tshuaj ntsuam xyuas (SynKit) | ES-NHT-2400 | ib txheej ntawm 24 Nnitrile Hydratases, 1 mg txhua 24 yam khoom * 1mg / khoom |
★ High substrate specification.
★ Muaj zog chiral selectivity.
★ Kev hloov pauv siab.
★ Tsawg los ntawm cov khoom lag luam.
★ Cov tshuaj tiv thaiv me me.
★ Ib puag ncig tus phooj ywg.
➢ Nquag, cov txheej txheem tshuaj tiv thaiv yuav tsum suav nrog substrate, tsis muaj tshuaj (pH zoo tshaj plaws) thiab ES-NHT.
➢ Tag nrho cov ES-NHT tuaj yeem kuaj tau raws li hauv cov txheej txheem tshuaj tiv thaiv saum toj no lossis nrog NHT Kev Ntsuas Cov Khoom Siv (SynKit NHT).
➢ Txhua yam ntawm ES-NHTs sib haum rau ntau yam kev xav tau zoo yuav tsum tau kawm ib tus zuj zus.
➢ High concentration Substrate los yog khoom nrog tej zaum yuav inhibit ES-NHT cov kev ua.Txawm li cas los xij, qhov inhibition tuaj yeem daws tau los ntawm batch ntxiv ntawm substrate, coupling nrog amidases lossis cov khoom rho tawm.
Piv txwv 1 (coupling nrog cov amidase)(1):
Piv txwv 2(2):
Khaws 2 xyoos qis dua -20 ℃.
Tsis txhob tiv tauj nrog huab cua xws li: kub siab, siab / qis pH thiab siab concentration organic hnyav.
1 Vojtech V, Ludmila M, Alicja BV, e tal.J Mol Catal B-enzym, 2011, 71:51-55.
2 Gary WB, Thomas G, Christopher B. M, et al.Tetrahedron lett, 2010, 51: 1639-1641.
