Amine Dehydrogenase (AmDH)
Kev Piav Qhia Luv:
Txog Amine Dehydrogenase
ES-AmDH (Amine Dehydrogenase): ib qho enzyme uas tuaj yeem ua rau cov ammoniation ntawm pawg carbonyl thiab txo nws mus rau amino pawg. Nws yog ib qho coenzyme NADH dependent enzyme, thiab NADH ua haujlwm ua lub tshuab xa hydrogen. Muaj 4 hom khoom AmDH enzyme (Tus lej ua ES-AmDH101 ~ ES-AmDH104) tsim los ntawm SyncoZymes, uas tuaj yeem siv rau hauv regioselective lossis stereoselective reductive amination ntawm aldehydes thiab ketones.
Hom tshuaj tiv thaiv catalytic:
Xov tooj ntawm tes/Wechat/WhatsApp: +86-13681683526
Email:lchen@syncozymes.com
★ Kev tshwj xeeb ntawm cov substrate siab.
★ Muaj zog xaiv chiral.
★ Kev hloov pauv siab heev.
★ Cov khoom tsis muaj txiaj ntsig tsawg dua.
★ Cov mob ua xua me me.
★ Ib puag ncig zoo.
➢ Feem ntau, lub kaw lus tshuaj tiv thaiv yuav tsum muaj cov khoom siv substrate, buffer solution, enzyme, coenzyme thiab coenzyme regeneration system (piv txwv li glucose thiab glucose dehydrogenase).
➢ Yuav tsum ntxiv AmDH rau hauv qhov system tshuaj tiv thaiv tom qab pH thiab qhov kub tau hloov kho rau qhov xwm txheej tshuaj tiv thaiv.
Piv txwv 1 (Kev tsim cov chiral amines sib xws los ntawm kev txo cov alkyl aryl ketones)(1):
Khaws cia rau 2 xyoos hauv qab -20 ℃.
Tsis txhob kov cov xwm txheej hnyav xws li: kub heev, pH siab / qis thiab cov kuab tshuaj organic siab.
1. Kong W, Liu Y, Huang C, et al. Angewandte Chemie International Edition, 2022: e202202264.
