Amine Dehydrogenase (AmDH)
Lus piav qhia luv luv:
Hais txog Amine Dehydrogenase
ES-AmDH (Amine Dehydrogenase): ib qho enzyme uas tuaj yeem ua rau cov amoniation ntawm carbonyl pawg thiab txo nws mus rau cov amino pawg.Nws yog ib qho coenzyme NADH nyob ntawm enzyme, thiab NADH ua raws li hydrogen transmitter.Muaj 4 yam khoom AmDH enzyme (Ntau li ES-AmDH101～ES-AmDH104) tsim los ntawm SyncoZymes, uas tuaj yeem siv rau hauv regioselective lossis stereoselective reductive amination ntawm aldehydes thiab ketones.
Catalytic tshuaj tiv thaiv hom:
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E-Mail:lchen@syncozymes.com
★ High substrate specification.
★ Muaj zog chiral selectivity.
★ Kev hloov pauv siab.
★ Tsawg los ntawm cov khoom lag luam.
★ Cov tshuaj tiv thaiv me me.
★ Ib puag ncig tus phooj ywg.
➢ Feem ntau, cov tshuaj tiv thaiv kab mob yuav tsum muaj xws li substrate, tsis muaj tshuaj, enzyme, coenzyme thiab coenzyme regeneration system (xws li qabzib thiab qabzib dehydrogenase).
➢ AmDH yuav tsum muab ntxiv rau qhov kawg ntawm cov tshuaj tiv thaiv kab mob, tom qab pH thiab qhov kub thiab txias tau hloov kho rau cov tshuaj tiv thaiv.
Piv txwv 1 (Synthesis of corresponding chiral amines by reductive amination of alkyl aryl ketones)(1):
Khaws 2 xyoos qis dua -20 ℃.
Tsis txhob tiv tauj nrog huab cua xws li: kub siab, siab / qis pH thiab siab concentration organic hnyav.
1. Kong W, Liu Y, Huang C, et al.Angewandte Chemie International Edition, 2022: e202202264.
