Esterase & Lipase (PLE & CALB)

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Hais txog Esterase & Lipase

ES-PLEs: Ib chav kawm ntawm hydrolases uas catalyze tsim thiab tawg ntawm ester bonds.Lawv tuaj yeem koom nrog ntau hom tshuaj lom neeg biochemical, xws li esterification, transesterification thiab hydrolysis.Lawv tau siv dav hauv ntau qhov chaw xws li kev ua zaub mov, kev lag luam tshuaj, biomedicine, chiral tshuaj thiab kev kho ib puag ncig.

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Khoom cim npe

Hais txog Esterase & Lipase:

Muaj 26 hom PLE enzyme cov khoom lag luam (Tus lej li ES-PLE-101～ES-PLE-126) tsim los ntawm SyncoZymes.ES-PLE tuaj yeem siv rau hydrolysis ntawm aliphatic thiab ester compounds, los yog regioselective thiab stereoselective daws teeb meem los ua ke chiral acids thiab lawv cov derivatives.

Catalytic tshuaj tiv thaiv hom:

Qhov zoo:

★ High substrate specification.
★ Muaj zog chiral selectivity.
★ Kev hloov pauv siab.
★ Tsawg los ntawm cov khoom lag luam.
★ Cov tshuaj tiv thaiv me me.
★ Ib puag ncig tus phooj ywg.

Cov lus qhia rau kev siv:

➢ Nquag, cov txheej txheem tshuaj tiv thaiv yuav tsum suav nrog substrate, tsis muaj tshuaj thiab ES-PLE.Lub esterification ntawm ib co ES-PLEs yog ua nyob rau hauv lub organic theem.
➢ Txhua yam ntawm ES-PLEs cuam tshuam rau ntau yam kev xav tau zoo yuav tsum tau kawm ib tus zuj zus.

Piv txwv daim ntawv thov:

Piv txwv 1 (Biosynthesis ntawm Pregabalin Intermediate)⁽¹⁾:

Piv txwv 2⁽²⁾:

Piv txwv 3⁽³⁾:

Piv txwv 4⁽⁴⁾:

Cia:

Khaws 2 xyoos qis dua -20 ℃.

Nco ntsoov:

Tsis txhob tiv tauj nrog huab cua xws li: kub siab, siab / qis pH.

Cov ntaub ntawv:

1. Xu FX, Chen SY, Xu G, e tal.Appl.Biotechnol Bioproc E, 1988, 54(4): 1030.
2. Huang, FC, Lee, LF, Mittal, RSD et tal.J. Am.Chem.Soc, 1975, 97, 4144.
3. Kielbasinski, P., Goralczyk, P., Mikolajczyk, M., e tal.Synlett, 1994, 127.
4. Gais, HJ, Griebel, C., Buschmann, H. Tetrahedron: Asymmetry 2000, 11, 917

Yav dhau los: Epoxide hydrolase (EH)

Tom ntej: Formate dehydrogenase (FDH)

Sau koj cov lus ntawm no thiab xa tuaj rau peb