Imine reductase (IRED)
Lus piav qhia luv luv:
Hais txog Imine reductase
ES-IRED: Ib chav kawm ntawm cov enzymes uas ua rau txo qis ntawm C = N daim ntawv cog lus rau CN daim ntawv cog lus.Nws belongs rau redox enzyme, nrog coenzyme NADPH rau kev thauj mus los hydrogen.Raws li chiral nyiam ntawm cov khoom, lawv tuaj yeem muab faib ua R-IRED thiab S-IRED.Syncozymes tsim 15 imine reductases (numbIRED ES-IRED-101-ES-IRED-115), uas tuaj yeem siv dav hauv regioselective thiab stereoselective txo ntawm imines los npaj chiral amines.
Catalytic tshuaj tiv thaiv hom:
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E-Mail:lchen@syncozymes.com
| Enzymes | Khoom Code | Specification |
| Enzyme hmoov | ES-IRED-101 ~ ES-IRED-114 | ib txheej ntawm 14 Imine Reductase, 50 mg txhua |
| 96-Zoo Enzyme kuaj cov khoom siv | ES-IRED-1400 | ib txheej ntawm 14 Imine Reductase, 1 mg txhua |
★ High substrate specification.
★ Muaj zog chiral selectivity.
★ Kev hloov pauv siab.
★ Tsawg los ntawm cov khoom lag luam.
★ Cov tshuaj tiv thaiv me me.
★ Ib puag ncig tus phooj ywg.
➢ Nquag, cov tshuaj tiv thaiv yuav tsum muaj xws li substrate, tsis muaj tshuaj, enzyme, coenzyme, thiab coenzyme regeneration system.
➢ Txhua yam ntawm ES-IREDs cuam tshuam rau ntau yam kev pom zoo yuav tsum tau kawm ib tus zuj zus.
➢ High concentration Substrate los yog khoom nrog tej zaum yuav inhibit ES-IRED cov kev ua.Txawm li cas los xij, qhov inhibition tuaj yeem daws tau los ntawm batch ntxiv ntawm substrate.
Piv txwv 1 (Biosynthesis ntawm chiral 2-methyl pyrrolidine)(1):
Piv txwv 2 (Biosynthesis ntawm Secondary amine)(2):
Piv txwv 3 (Txo ntawm Cyclic Imines)(3):
Khaws 2 xyoos qis dua -20 ℃.
Tsis txhob tiv tauj nrog huab cua xws li: kub siab, siab / qis pH thiab siab concentration organic hnyav.
1. Scheller PN, Fademrecht S, Hofelzer S, thiab al.ChemBioChem, 2014, 15, 2201-2204.
2. Wetzl D, Gand M, Ross A, et al.ChemCatChem, 2016, 8, 2023-2026.
3. Li H, Luan ZJ, Zheng GW, et al.Adv.Synth.Catal.2015, 357, 1692-1696.
